redesigning of natural product biosynthetic blueprints
We are part of the Institute of Molecular Bioscience at Goethe University Frankfurt am Main, Germany and the LOEWE Center for Translational Biodiversity Genomics. Our interdisciplinary team works at the interface of bioinformatics, microbiology, molecular biology, chemical ecology, synthetic biology, analytical and organic chemistry. We develop tools and workflows for the identification of novel bioactive metabolites from a wide variety of bacterial phyla and diverse ecological niches. In addition, we are interested in deciphering the genetic blueprints that govern their biosynthesis and aim at understanding the role of the identified natural products in their native environment.